Continuous infusion of recombinant activated factor VII for bleeding control after lobectomy in a patient with inherited factor VII deficiency

Gen Thorac Cardiovasc Surg. 2016 Mar;64(3):177-80. doi: 10.1007/s11748-014-0455-1. Epub 2014 Jul 24.

Abstract

Inherited factor VII (FVII) deficiency is a rare recessive inherited coagulation disorder with limited available information, especially in patients undergoing major thoracic surgery. In addition, an optimal management strategy for the disease has not been defined. We herein report a case involving a 61-year-old man with asymptomatic FVII deficiency who underwent a right middle and lower lobectomy to treat lung cancer. To the best of our knowledge, the present report is the first to describe the use of recombinant activated FVII continuous infusion for bleeding control after a major thoracic surgery in a patient with inherited FVII deficiency.

Keywords: Continuous infusion; Inherited factor VII deficiency; Lobectomy; Recombinant activated factor VII.

Publication types

  • Case Reports

MeSH terms

  • Factor VII / metabolism*
  • Factor VII Deficiency / blood
  • Factor VII Deficiency / complications*
  • Factor VII Deficiency / drug therapy
  • Factor VIIa / administration & dosage*
  • Hemorrhage / blood
  • Hemorrhage / etiology
  • Hemorrhage / prevention & control*
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Pneumonectomy / adverse effects*
  • Postoperative Hemorrhage / blood
  • Postoperative Hemorrhage / etiology
  • Postoperative Hemorrhage / prevention & control*
  • Rare Diseases
  • Recombinant Proteins / administration & dosage

Substances

  • Recombinant Proteins
  • Factor VII
  • recombinant FVIIa
  • Factor VIIa