Role of SOX family of transcription factors in central nervous system tumors

Am J Cancer Res. 2014 Jul 16;4(4):312-24. eCollection 2014.


SOX genes are developmental regulators with functions in the instruction of cell fate and maintenance of progenitor's identity during embryogenesis. They play additional roles during tissue homeostasis and regeneration in adults particularly in the Central Nervous System (CNS). In the last years a growing number of evidences has shown that mutations and dysfunction of SOX factors are implicated in several human diseases, including a variety of cancers. In this review, we will summarize the current knowledge about SOX family in CNS tumors and their role in the origin and maintenance of the subpopulation of cancer stem cells in these tumors.

Keywords: CNS tumors; SOX; cell of origin; glioblastoma; glioma stem cell; oncogenic SOX2; therapy target.

Publication types

  • Review