Dopaminergic modulation of striatal networks in health and Parkinson's disease

Curr Opin Neurobiol. 2014 Dec:29:109-17. doi: 10.1016/j.conb.2014.07.008. Epub 2014 Jul 22.


In the last couple of years, there have been significant advances in our understanding of how dopamine modulates striatal circuits underlying goal-directed behaviors and how therapeutic interventions intended to normalize disordered dopaminergic signaling can go awry. This review summarizes some of the advances in this field with a translational focus on Parkinson's disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Corpus Striatum / metabolism
  • Corpus Striatum / pathology*
  • Dopamine / metabolism*
  • Humans
  • Nerve Net / metabolism*
  • Parkinson Disease / pathology*
  • Signal Transduction / physiology


  • Dopamine