A chemical switch for controlling viral infectivity

Chem Commun (Camb). 2014 Sep 14;50(71):10319-22. doi: 10.1039/c4cc03292f.


Chemically triggered molecular switches for controlling the fate and function of biological systems are fundamental to the emergence of synthetic biology and the development of biomedical applications. We here present the first chemically triggered switch for controlling the infectivity of adeno-associated viral (AAV) vectors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Dependovirus / chemistry*
  • Dependovirus / genetics
  • Genetic Vectors / chemistry*
  • Genetic Vectors / genetics
  • Humans
  • Protein Structure, Secondary
  • Tacrolimus Binding Proteins / genetics


  • Tacrolimus Binding Proteins