[Insulin-phospholipid interactions. A study in monolayers by measuring surface potential]

C R Acad Sci III. 1989;309(5):157-63.
[Article in French]


Surface potential (delta V) measurements were performed to assess information on insulin penetration/interaction with dipalmitoylphosphatidylcholine (DPPC) monolayers spread at the water-air interface. The results reveal existence of the threshold surface density value of spread lipid molecules (7.5 x 10(13) molecules/cm2) above which none penetration of insulin molecules occurs. Surface potential data clearly indicate also that insulin penetration/interaction with DPPC monolayers is enhanced in the presence of the second studied constituent of these monolayers in the order DPPC + stearylamine greater than DPPC + cholesteryl betainate greater than DPPC + cholesterol greater than DPPC. The results clearly indicate the existence of two types of phospholipid-insulin interactions namely: adsorption and penetration.

Publication types

  • English Abstract

MeSH terms

  • 1,2-Dipalmitoylphosphatidylcholine / pharmacokinetics
  • Action Potentials
  • Adsorption
  • Amines / pharmacokinetics
  • Biological Transport, Active
  • Cholesterol / pharmacokinetics
  • Drug Interactions
  • Insulin / metabolism*
  • Insulin / pharmacokinetics
  • Pharmaceutical Vehicles
  • Phospholipids / metabolism*
  • Phospholipids / pharmacokinetics


  • Amines
  • Insulin
  • Pharmaceutical Vehicles
  • Phospholipids
  • 1,2-Dipalmitoylphosphatidylcholine
  • Cholesterol
  • stearylamine