High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production

Clin Exp Immunol. 1989 Aug;77(2):221-5.


Hypergammaglobulinaemia and enhanced serum IgA levels are common in alcoholic liver cirrhosis. Interleukin-6 (IL-6), which is identical to B cell differentiation factor BSF2 and is implicated in various autoimmune diseases, has been studied in patients with alcoholic liver cirrhosis. Increased serum levels and spontaneous or induced production of IL-6 by peripheral blood monoclonal cells have been found. IL-6 production correlates closely with IgA serum levels and negatively with impaired interleukin-2 and interferon gamma production. This abnormality could be related to overproduction of immunoglobulins and immune disturbances observed in this disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Humans
  • Immunoglobulin A / analysis*
  • Interferon-gamma / blood
  • Interleukin-2 / analysis
  • Interleukin-6
  • Interleukins / analysis*
  • Interleukins / biosynthesis
  • Leukocytes, Mononuclear / metabolism*
  • Liver Cirrhosis, Alcoholic / immunology*
  • Lymphokines / blood*
  • Male
  • Middle Aged


  • Immunoglobulin A
  • Interleukin-2
  • Interleukin-6
  • Interleukins
  • Lymphokines
  • Interferon-gamma