LeA(H)Rning self-control

Cell Res. 2014 Oct;24(10):1155-6. doi: 10.1038/cr.2014.96. Epub 2014 Jul 25.


The aryl hydrocarbon receptor (AhR) is an important regulator of the immune response. A report by Puccetti and coworkers describes a regulatory pathway by which L-kynurenine (L-Kyn) produced by tryptophan 2,3-dioxygenase 2 (TDO2) activates AhR in cells of the innate immune system to limit endotoxin-triggered inflammation through a mechanism that involves the non-enzymatic anti-inflammatory activities of indoleamine 2,3-dioxygenase 1 (IDO1).

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Lipopolysaccharides / pharmacology*
  • Macrophages / drug effects*
  • Macrophages / immunology*
  • Receptors, Aryl Hydrocarbon / metabolism*
  • Shock, Septic / chemically induced*


  • Lipopolysaccharides
  • Receptors, Aryl Hydrocarbon