Meta-analysis of the risk of cataract in type 2 diabetes

BMC Ophthalmol. 2014 Jul 24;14:94. doi: 10.1186/1471-2415-14-94.

Abstract

Background: This meta-analysis aimed to investigate the association between type 2 diabetes (T2D) and the risk of cataract.

Methods: Databases of Pubmed, Embase, and SpringerLink were retrieved for observational studies published before November 2013. The odds ratio (OR) and 95% confidence interval (CI) were used for estimating the association. All statistical analyses were performed by Stata 10.0 software.

Results: A total of 8 studies involving 20837 subjects were included in the meta-analysis. The risk of any cataract (AC) in T2D patients was higher than that in non-diabetic subjects (OR = 1.97, 95% CI: 1.45-2.67, P < 0.001). The risks of cortical cataract posterior (CC) (OR = 1.68, 95% CI: 1.47-1.91, P < 0.001) and posterior subcapsular (PSC) (OR = 1.55, 95% CI: 1.27-1.90, P < 0.001) were significantly elevated in T2D patients, while no significant association was found in nuclear sclerosis (NS) (OR = 1.36, 95% CI: 0.97-1.90, P = 0.070).

Conclusion: T2D patients had a higher risk of cataracts, excepting NS. Special attention should be paid on the ophthalmic extermination, especially for cataract in T2D patients.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Aging*
  • Cataract / epidemiology
  • Cataract / etiology*
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Global Health
  • Humans
  • Incidence
  • Odds Ratio
  • Prevalence
  • Risk Assessment*
  • Risk Factors