Serum levels of apolipoprotein A-I, A-II and HDL-cholesterol in second half of normal pregnancy and in pregnancy complicated by pre-eclampsia

Horm Metab Res. 1989 Jul;21(7):376-82. doi: 10.1055/s-2007-1009242.


Serum concentrations of Apolipoprotein A-I and A-II, (Apo A-1 and Apo A-II) HDL-cholesterol (HDL-C), Total Cholesterol (TC), triglycerides (TG) and lipoprotein electrophoresis were assayed serially in the second half of normal pregnancy (21 women), in pre-eclampsia (26 women) and in both groups one and six weeks after delivery. In the normal group we found increased concentrations of Apo A-I and HDL-C, which remained unaltered during pregnancy. Apo A-II was unchanged. Correlation coefficients for Apo A-II vs HDL-C and Apo A-I vs Apo A-II decreased gradually towards delivery while it remained at an elevated and unaltered level for Apo A-I vs HDL-C. The Apo A-I/HDL-C ratio was unaltered during the whole study while the Apo A-I/A-II ratio was elevated during pregnancy and the Apo A-II/HDL-C ratio was reduced. These results may indicate a gradual change in the surface structure of the HDL particle or its subfractions. In pre-eclampsia Apo A-I and HDL-C concentrations were reduced, TG was increased and Apo A-II and TC were unchanged when compared with the normal pregnancy group. A more pronounced correlation coefficient was recorded for Apo A-I vs HDL-C than for Apo A-II vs HDL-C and Apo A-I vs Apo II. The results indicate that from an atherogenic point of view normal pregnancy seems more beneficial than pre-eclampsia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoprotein A-I
  • Apolipoprotein A-II
  • Apolipoproteins A / blood*
  • Cholesterol / blood
  • Cholesterol, HDL / blood*
  • Female
  • Humans
  • Lactation / blood
  • Lipoproteins, LDL / blood
  • Postpartum Period / blood
  • Pre-Eclampsia / blood*
  • Pregnancy / blood*
  • Pregnancy Trimester, Second
  • Pregnancy Trimester, Third
  • Triglycerides / blood


  • Apolipoprotein A-I
  • Apolipoprotein A-II
  • Apolipoproteins A
  • Cholesterol, HDL
  • Lipoproteins, LDL
  • Triglycerides
  • Cholesterol