Levofloxacin-resistant haemophilus influenzae, Taiwan, 2004-2010

Emerg Infect Dis. 2014 Aug;20(8):1386-90. doi: 10.3201/eid2008.140341.

Abstract

Levofloxacin resistance in Haemophilus influenzae has increased significantly in Taiwan, from 2.0% in 2004 to 24.3% in 2010 (p<0.001). Clinical and molecular investigations of 182 levofloxacin-resistant isolates revealed that the increase was mainly the result of the spread of several clones in the elderly population in different regions.

Keywords: GyrA; Haemophilus influenzae; ParC; Taiwan; antimicrobial resistance; bacteria; fluoroquinolone resistance; levofloxacin; respiratory infections.

Publication types

  • Historical Article
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology*
  • Cluster Analysis
  • Cross Infection
  • Drug Resistance, Bacterial*
  • Electrophoresis, Gel, Pulsed-Field
  • Haemophilus Infections / epidemiology*
  • Haemophilus Infections / history
  • Haemophilus Infections / microbiology*
  • Haemophilus influenzae / classification
  • Haemophilus influenzae / drug effects*
  • Haemophilus influenzae / genetics
  • Haemophilus influenzae / isolation & purification
  • History, 21st Century
  • Humans
  • Levofloxacin / pharmacology*
  • Middle Aged
  • Multilocus Sequence Typing
  • Public Health Surveillance
  • Taiwan / epidemiology

Substances

  • Anti-Bacterial Agents
  • Levofloxacin