New amino butenolides from the bulbs of Fritillaria unibracteata

Fitoterapia. 2014 Oct:98:53-8. doi: 10.1016/j.fitote.2014.07.009. Epub 2014 Jul 23.

Abstract

Five new amino γ-butenolides, fritenolide A (1), B (2), C (3), D (4), and E (5), along with four known compounds, were isolated from the bulbs of Fritillaria unibracteata. Their structures were determined by spectroscopic analysis, including 1D NMR, 2D NMR, HRESIMS, HRESIMS/MS, IR, and CD techniques. All isolates were evaluated for the protective activity on injured hepatocytes and cytotoxic activity on human cancer cells in vitro. The unusual amino butenolides were isolated from the Liliaceae family for the first time.

Keywords: Amide alkaloids; Amino butenolides; Fritillaria unibracteata; Liliaceae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / isolation & purification
  • Amines / chemistry*
  • Amines / isolation & purification
  • Cell Line, Tumor
  • Fritillaria / chemistry*
  • Hepatocytes / drug effects
  • Humans
  • Molecular Structure
  • Plant Roots / chemistry*

Substances

  • Amines
  • butenolide
  • 4-Butyrolactone