Clinical and histological findings associated with autoantibodies detected by RNA immunoprecipitation in inflammatory myopathies

J Neuroimmunol. 2014 Sep 15;274(1-2):202-8. doi: 10.1016/j.jneuroim.2014.07.006. Epub 2014 Jul 17.


Of 207 adult patients with idiopathic inflammatory myopathies, detection of autoantibodies by RNA immunoprecipitation showed that 99 patients (48%) were antibody-positive. We divided these 99 into five subgroups: anti-signal recognition particle (SRP), anti-aminoacyl transfer RNA synthetase, anti-Ku, anti-U1RNP, and anti-SSA/B. Younger age at onset, severe weakness, muscle atrophy, elevated creatine kinase, and necrosis in muscle fibers without inflammatory cell infiltration were found significantly more frequently among the patients with anti-SRP antibodies (n=41) compared to the antibody-negative patients (n=108). Autoantibody detection by RNA immunoprecipitation can provide useful information associated with clinical and histological findings.

Keywords: Autoantibodies; Inflammatory myopathies; Muscle biopsy; Necrotizing myopathy; RNA immunoprecipitation; Signal recognition particle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Autoantibodies / immunology*
  • Chromatin Immunoprecipitation / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscular Atrophy / immunology
  • Muscular Atrophy / pathology
  • Myelitis, Transverse / immunology*
  • Myelitis, Transverse / pathology
  • Myositis / immunology*
  • Myositis / pathology
  • RNA
  • Signal Recognition Particle / immunology


  • Autoantibodies
  • Signal Recognition Particle
  • RNA