Old medications and new targeted therapies in systemic sclerosis

Rheumatology (Oxford). 2015 Nov;54(11):1944-53. doi: 10.1093/rheumatology/keu285. Epub 2014 Jul 26.


SSc is a multiorgan disease with significant morbidity that is associated with poor health-related quality of life. Treatment of this condition is often organ based and non-curative. However, there are newer, potentially disease-modifying therapies available to treat certain aspects of the disease. This review focuses on old and new therapies in the management of SSc in clinical practice.

Keywords: Raynaud’s phenomenon; digital ulcers; immunosuppressive therapy; interstitial lung disease; pulmonary arterial hypertension; renal crisis; skin fibrosis; systemic sclerosis; treatment.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antirheumatic Agents / therapeutic use*
  • Drug Therapy / trends*
  • Fibrosis / etiology
  • Humans
  • Scleroderma, Systemic / complications
  • Scleroderma, Systemic / diagnosis
  • Scleroderma, Systemic / drug therapy*
  • Skin / pathology
  • Vascular Diseases / etiology


  • Antirheumatic Agents