Neuroendocrine tumors of the lung: the role of surgery in small cell lung cancer

Thorac Surg Clin. 2014 Aug;24(3):313-26. doi: 10.1016/j.thorsurg.2014.05.004.

Abstract

The role of surgery in the management of patients with SCLC remains controversial. Although 2 randomized studies have failed to show any benefit on survival by adding surgery to chemotherapy, retrospective and prospective reports showed that surgery offers a reasonable overall survival in a subset of patients with stage I and II SCLC. Patients' selection is fundamental, and it should include extensive radiologic staging and mediastinal lymph-node biopsy. The use of a PET scan is likely to improve the accuracy of staging. Through primary surgery or after induction chemotherapy, a complete tumor resection associated with systematic lymphadenectomy should be achieved.

Keywords: Indications; Results; Small cell lung cancer; Staging; Surgery.

Publication types

  • Review

MeSH terms

  • Humans
  • Lung Neoplasms / pathology
  • Lung Neoplasms / surgery*
  • Lymph Node Excision
  • Lymph Nodes / pathology
  • Mediastinum
  • Neoplasm Staging
  • Neuroendocrine Tumors / pathology
  • Neuroendocrine Tumors / surgery*
  • Pneumonectomy
  • Positron-Emission Tomography
  • Small Cell Lung Carcinoma / pathology
  • Small Cell Lung Carcinoma / surgery*