Nuclear receptor Rev-erbα: up, down, and all around

Trends Endocrinol Metab. 2014 Nov;25(11):586-92. doi: 10.1016/j.tem.2014.06.011. Epub 2014 Jul 22.


Rev-erbα is a nuclear receptor that links circadian rhythms to transcriptional control of metabolic pathways. Rev-erbα is a potent transcriptional repressor and plays an important role in the core mammalian molecular clock while also serving as a key regulator of clock output in metabolic tissues including liver and brown adipose tissue (BAT). Recent findings have shed new light on the role of Rev-erbα and its paralog Rev-erbβ in rhythm generation, as well as additional regulatory roles for Rev-erbα in other tissues that contribute to energy expenditure, inflammation, and behavior. This review highlights physiological functions of Rev-erbα and β in multiple tissues and discusses the therapeutic potential and challenges of targeting these pathways in human disease.

Keywords: Rev-erbα; circadian rhythm; metabolism; nuclear receptor; transcriptional regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biological Clocks / genetics
  • Circadian Rhythm / genetics
  • Energy Metabolism / genetics
  • Epigenesis, Genetic / genetics
  • Gene Expression Regulation
  • Humans
  • Lipid Metabolism / genetics
  • Muscle, Skeletal / metabolism
  • Nuclear Receptor Subfamily 1, Group D, Member 1 / physiology*


  • Nuclear Receptor Subfamily 1, Group D, Member 1