Anti-inflammatory lignanamides from the roots of Solanum melongena L

Fitoterapia. 2014 Oct:98:110-6. doi: 10.1016/j.fitote.2014.07.012. Epub 2014 Jul 25.

Abstract

Four new lignanamides, melongenamides A-D (1-4), together with six known ones (5-10), were isolated from the roots of Solanum melongena L. Their structures were elucidated on the basis of 1D and 2D NMR experiments and by comparison of their spectroscopic and physical data with the literature values. Compounds 2-8 exhibited inhibitions of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values ranging from 16.2 to 58.5 μM.

Keywords: Anti-inflammation; Cannabisin D (PubChem CID: 44584134); Cannabisin F (PubChem CID: 71448967); Cannabisin G (PubChem CID: 10438919); Grossamide (PubChem CID: 6440658); Lignanamide; Solanaceae; Solanum melongena L..

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Amides / isolation & purification
  • Amides / pharmacology
  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Inhibitory Concentration 50
  • Lignans / chemistry*
  • Lignans / isolation & purification
  • Lignans / pharmacology
  • Macrophages / drug effects*
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Plant Roots / chemistry
  • Solanum melongena / chemistry*

Substances

  • Amides
  • Anti-Inflammatory Agents
  • Lignans
  • Nitric Oxide