Metacarpophalangeal joint osteoarthritis is a relatively common condition that hand surgeons have to deal with. When daily activities are impaired by pain and all conservative measures have failed, surgical treatments such as arthrodesis or joint replacement are indicated. In this article, a technique for joint denervation is presented as a treatment for painful degenerative or posttraumatic osteoarthritis. Its preliminary results, potential complications, and contraindications are also discussed.