Updated international clinical recommendations on scar management: part 1--evaluating the evidence

Dermatol Surg. 2014 Aug;40(8):817-24. doi: 10.1111/dsu.0000000000000049.


Background: There is an ongoing need to standardize scar management by establishing safe and effective treatment options that can be applied in routine clinical practice.

Objective: To review available data on methods for preventing and treating cutaneous scarring.

Materials and methods: Relevant scientific literature was identified through a comprehensive search of the MEDLINE database. Additional data and published studies were submitted for consideration by members of the International Advisory Panel on Scar Management.

Results: One of the most significant advances in scar management over the past 10 years has been the broader application of laser therapy, resulting in a shift in status from an emerging technology to the forefront of treatment. Accumulated clinical evidence also supports a greater role for 5-fluourouracil in the treatment of hypertrophic scars and keloids, particularly in combination with intralesional corticosteroids. Encouraging data have been reported for newer therapies, including bleomycin, onion extract-containing preparations, imiquimod, and mitomycin C, although methodologic limitations in available studies merit consideration. In general, clinical and aesthetic outcomes seem to be enhanced by a combination approach to treatment.

Conclusion: Advances in therapeutic options and new study data necessitate a revision of algorithms for the prevention and management of cutaneous scarring.

Publication types

  • Review

MeSH terms

  • Cicatrix / therapy*
  • Evidence-Based Medicine*
  • Humans
  • Practice Guidelines as Topic*
  • Skin Physiological Phenomena