Flavone composition and antihypercholesterolemic and antihyperglycemic activities of Chrysanthemum coronarium L

Z Naturforsch C J Biosci. 2014 May-Jun;69(5-6):199-208. doi: 10.5560/znc.2013-0115.


Five flavones were isolated from Chrysanthemum coronarium L., four of which were isolated for the first time from the genus Chrysanthemum. Two were the flavonoid aglycones 5,7-dihydroxy-3,6,4'-trimethoxyflavone (1) and scutellarin-6,7-dimethyl ether (2). A new flavonoid glycoside, apigenin-7-O-[2"(6'''-O-beta-D-acetylglucopyranosyl)]-6"-O-acetylglucopyranoside (3), along with two known ones, i. e. apigenin-7-O-(2"-O-beta-D-glucopyranosyl)-beta-D-glucopyranoside (4) and 6-methoxy quercetin-7-O-beta-D-glucopyranoside (5), were identified. Structures were elucidated by NMR and MS. The therapeutic value of petroleum ether, ethyl acetate, and methanol extracts, respectively, in rats suffering from hypercholesterolemia--as a consequence of high-fat diet-and hyperglycemia--as a consequence of hypercholesterolemia and low doses of streptozotocin--was investigated through determination of biochemical markers and histopathology. The ethyl acetate and methanol extracts showed remarkable results, followed by the petroleum ether extract.

MeSH terms

  • Animals
  • Anticholesteremic Agents / chemistry
  • Anticholesteremic Agents / isolation & purification*
  • Anticholesteremic Agents / pharmacology
  • Chrysanthemum / chemistry*
  • Flavones / analysis*
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / isolation & purification*
  • Hypoglycemic Agents / pharmacology
  • Magnetic Resonance Spectroscopy
  • Male
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification*
  • Plant Extracts / pharmacology
  • Rats
  • Rats, Wistar
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Ultraviolet


  • Anticholesteremic Agents
  • Flavones
  • Hypoglycemic Agents
  • Plant Extracts