Population pharmacokinetics of abacavir in pregnant women

Antimicrob Agents Chemother. 2014 Oct;58(10):6287-9. doi: 10.1128/AAC.03469-14. Epub 2014 Jul 28.


For the first time, a population approach was used to describe abacavir (ABC) pharmacokinetics in HIV-infected pregnant and nonpregnant women. A total of 266 samples from 150 women were obtained. No covariate effect (from age, body weight, pregnancy, or gestational age) on ABC pharmacokinetics was found. Thus, it seems unnecessary to adapt the ABC dosing regimen during pregnancy.

MeSH terms

  • Anti-HIV Agents / pharmacokinetics*
  • Anti-HIV Agents / therapeutic use
  • Dideoxynucleosides / pharmacokinetics*
  • Dideoxynucleosides / therapeutic use
  • Female
  • HIV Infections / drug therapy
  • Humans
  • Pregnancy


  • Anti-HIV Agents
  • Dideoxynucleosides
  • abacavir