Pin1: a molecular orchestrator in the heart

Trends Cardiovasc Med. 2014 Aug;24(6):256-62. doi: 10.1016/j.tcm.2014.05.010. Epub 2014 Jun 4.


Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes. This review discusses the pivotal role Pin1 plays in regulating cardiac pathophysiology by functioning as a "molecular orchestrator" of a myriad of signal transduction pathways in the heart.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Physiological Phenomena
  • Humans
  • Myocardium / metabolism*
  • Peptidylprolyl Isomerase / metabolism*
  • Phosphoproteins / metabolism*
  • Phosphorylation / physiology
  • Signal Transduction


  • Phosphoproteins
  • Peptidylprolyl Isomerase