Trends in research of antitrypanosomal agents among synthetic heterocycles

Eur J Med Chem. 2014 Oct 6;85:51-64. doi: 10.1016/j.ejmech.2014.07.092. Epub 2014 Jul 25.

Abstract

To date treatment of trypanosomiasis urgently requires new effective and non-toxic drugs. The article covers some of the achievements in the search for new antitrypanosomal agents; also the "validated" biological targets used in the antitrypanosomal agents design are outlined. The major part of the manuscript focuses on the synthetic small molecules, such as thiosemicarbazone and thiazole (as their cyclic analogues) derivatives, benzofuran derivatives, heterocycles bearing nitro group etc. Also, the attractiveness of metal complexes and well known drugs as sources for antitrypanosomal agent design is discussed.

Keywords: Antitrypanosomal agents; Heterocyclic small molecules; Trypanosome targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chagas Disease / drug therapy
  • Drug Discovery / methods*
  • Drug Discovery / trends
  • Heterocyclic Compounds / chemical synthesis
  • Heterocyclic Compounds / chemistry
  • Heterocyclic Compounds / pharmacology*
  • Heterocyclic Compounds / therapeutic use
  • Humans
  • Trypanocidal Agents / chemical synthesis
  • Trypanocidal Agents / chemistry
  • Trypanocidal Agents / pharmacology*
  • Trypanocidal Agents / therapeutic use

Substances

  • Heterocyclic Compounds
  • Trypanocidal Agents