Palladium-catalyzed carbonylative addition of aryl bromides to arylalkynes: a simple and efficient method for chalcone synthesis

Sheng Zhang; Liangguang Wang; Xiujuan Feng; Ming Bao

doi:10.1039/c4ob01263a

Palladium-catalyzed carbonylative addition of aryl bromides to arylalkynes: a simple and efficient method for chalcone synthesis

Org Biomol Chem. 2014 Oct 7;12(37):7233-7. doi: 10.1039/c4ob01263a.

Authors

Sheng Zhang¹, Liangguang Wang, Xiujuan Feng, Ming Bao

Affiliation

¹ State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China. fengxiujuan@dlut.edu.cn mingbao@dlut.edu.cn.

PMID: 25072944
DOI: 10.1039/c4ob01263a

Abstract

Palladium-catalyzed carbonylative addition of aryl bromides to terminal arylalkynes was carried out to produce chalcones in satisfactory to excellent yields. The unprecedented carbonylation reaction proceeded smoothly under mild conditions in the presence of a simple palladium catalyst system (PdCl2/DPPB/(i)Pr2NEt) in N,N-dimethyl formamide.