Neuroimaging in patients with seizures of probable frontal lobe origin

Epilepsia. Sep-Oct 1989;30(5):547-58. doi: 10.1111/j.1528-1157.1989.tb05470.x.


Twenty-two patients whose electroclinical ictal characteristics suggested frontal lobe seizure foci were studied. Computed tomography (CT) scans showed abnormalities in only 32% of patients whereas magnetic resonance imaging was informative in 45%. 18FDG-Positron emission tomography (PET) scanning revealed decreased metabolism in 64% of the group. The areas of hypometabolism were focal, regional, or hemispheric. Focal frontal hypometabolism was significantly correlated with the electroclinical (semiologic) ictal localization. Therefore, FDG-PET scanning is a sensitive and specific technique for investigating patients with seizures of probable frontal lobe origins.

MeSH terms

  • Deoxyglucose / analogs & derivatives
  • Electroencephalography
  • Epilepsies, Partial / diagnosis*
  • Epilepsies, Partial / diagnostic imaging
  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • Frontal Lobe* / diagnostic imaging
  • Frontal Lobe* / pathology
  • Humans
  • Magnetic Resonance Imaging*
  • Television
  • Temporal Lobe / pathology
  • Tomography, Emission-Computed*
  • Tomography, X-Ray Computed*


  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • Deoxyglucose