Mother centrioles do a cartwheel to produce just one daughter

Jieyan V Chen; Timothy L Megraw

doi:10.1016/j.devcel.2014.07.013

Mother centrioles do a cartwheel to produce just one daughter

Dev Cell. 2014 Jul 28;30(2):111-2. doi: 10.1016/j.devcel.2014.07.013.

Authors

Jieyan V Chen¹, Timothy L Megraw²

Affiliations

¹ Department of Biomedical Sciences, Florida State University, 1115 West Call Street, Tallahassee, FL 32306-4300, USA.
² Department of Biomedical Sciences, Florida State University, 1115 West Call Street, Tallahassee, FL 32306-4300, USA. Electronic address: timothy.megraw@med.fsu.edu.

Abstract

In this issue of Developmental Cell, Fong et al. (2014) present evidence for a model of centriole duplication whereby the cartwheel-the starting building block in centriole biogenesis-assembles within the lumen of the mother centriole before templating the daughter centriole to ensure a single duplication event per cell cycle.

Publication types

Comment

MeSH terms

Centrioles / metabolism*
Humans

Grants and funding

R01 GM068756/GM/NIGMS NIH HHS/United States