Cloning, sequence analysis and chromosome localization of a Drosophila muscarinic acetylcholine receptor

FEBS Lett. 1989 Sep 25;255(2):219-25. doi: 10.1016/0014-5793(89)81095-6.

Abstract

Two cDNA clones (3.7 kb and 4.8 kb) encoding a Drosophila muscarinic acetylcholine receptor were isolated from a Drosophila head cDNA library and characterized by automated DNA sequence analysis. The Drosophila muscarinic receptor contains 788 amino acids with a calculated Mr of 84,807 and displays greater than 60% homology with mammalian muscarinic receptors. The muscarinic receptor maps to the tip of the right arm of the second chromosome of the Drosophila genome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping*
  • Cloning, Molecular*
  • DNA / genetics
  • Drosophila melanogaster / genetics*
  • Genes
  • Molecular Sequence Data
  • Protein Conformation
  • Receptors, Muscarinic / genetics*
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid
  • Software

Substances

  • Receptors, Muscarinic
  • DNA