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Case Reports
. 2014 Aug;34(8):4589-93.

Case Report: A Breast Cancer Patient Treated With GcMAF, Sonodynamic Therapy and Hormone Therapy

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  • PMID: 25075104
Case Reports

Case Report: A Breast Cancer Patient Treated With GcMAF, Sonodynamic Therapy and Hormone Therapy

Toshio Inui et al. Anticancer Res. .

Erratum in

  • Errata.
    Anticancer Res. 2015 Apr;35(4):2477. Anticancer Res. 2015. PMID: 25862917 No abstract available.

Abstract

Gc protein-derived macrophage-activating factor (GcMAF) occurs naturally in the human body. It has various functions, such as macrophage activation and antitumor activities. Recently, immunotherapy has become an attractive new strategy in the treatment of cancer. GcMAF-based immunotherapy can be combined with many other therapies. Sonodynamic therapy (SDT) using low-intensity ultrasound is a novel therapeutic modality. Ultrasound has been demonstrated to activate a number of sonosensitive agents allowing for the possibility of non-invasive targeted treatment for both superficial and deep-seated tumors. The current case study demonstrates that GcMAF and SDT can be used in combination with conventional therapies in patients with metastatic cancer, especially where treatment options are limited due to factors such as toxicity. This case study also suggests a new concept of cancer treatment using local destruction of cancer tissue, in this case conducted with SDT, to be used in combination with GcMAF immunotherapy as a systemic treatment.

Keywords: GeMAF; Immunotherapy; SDT; breast cancer; case report; macrophage; sonodynamic therapy.

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