Circleator: flexible circular visualization of genome-associated data with BioPerl and SVG

Bioinformatics. 2014 Nov 1;30(21):3125-7. doi: 10.1093/bioinformatics/btu505. Epub 2014 Jul 29.


Summary: Circleator is a Perl application that generates circular figures of genome-associated data. It leverages BioPerl to support standard annotation and sequence file formats and produces publication-quality SVG output. It is designed to be both flexible and easy to use. It includes a library of circular track types and predefined configuration files for common use-cases, including. (i) visualizing gene annotation and DNA sequence data from a GenBank flat file, (ii) displaying patterns of gene conservation in related microbial strains, (iii) showing Single Nucleotide Polymorphisms (SNPs) and indels relative to a reference genome and gene set and (iv) viewing RNA-Seq plots.

Availability and implementation: Circleator is freely available under the Artistic License 2.0 from and is integrated with the CloVR cloud-based sequence analysis Virtual Machine (VM), which can be downloaded from or run on Amazon EC2.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Computer Graphics
  • Gardnerella vaginalis / genetics
  • Genomics / methods*
  • Molecular Sequence Annotation
  • Polymorphism, Single Nucleotide
  • Sequence Analysis, DNA
  • Sequence Analysis, RNA
  • Software*