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Repurposing Drugs in Oncology (ReDO)-mebendazole as an Anti-Cancer Agent

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Repurposing Drugs in Oncology (ReDO)-mebendazole as an Anti-Cancer Agent

Pan Pantziarka et al. Ecancermedicalscience.

Abstract

Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types. Significantly, there are also two case reports of anti-cancer activity in humans. The data are summarised and discussed in relation to suggested mechanisms of action. Based on the evidence presented, it is proposed that mebendazole would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of mebendazole as an anti-cancer therapeutic is warranted. A number of possible combinations with other drugs are discussed in the Appendix.

Keywords: ReDO Project; anti-helminthic; cancer; drug repurposing; metronomic chemotherapy.

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