A rare association of celiac disease and aplastic anemia: case report of a child and review of literature

Pediatr Dev Pathol. 2014 Nov-Dec;17(6):470-3. doi: 10.2350/14-05-1489-CR.1. Epub 2014 Jul 30.

Abstract

An association between severe aplastic anemia and other autoimmune diseases is rare and has been described in adults for eosinophilic fasciitis, thymomas, systemic lupus erythematosus, and thyroid disorders. Herein we report a patient with celiac disease who was not strictly following a gluten-free diet and presented with progressive pallor, fever, and weakness of 1 month's duration. On investigation, he had pancytopenia, which on subsequent evaluation revealed aplastic anemia. An association between aplastic anemia and celiac disease has rarely been reported. To the best of author's knowledge, only 1 pediatric case of celiac disease associated with aplastic anemia has been published. This is the second report to suggest such an association in children.

Keywords: aplastic anemia; celiac disease; child; gluten-free diet.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anemia, Aplastic / complications*
  • Anemia, Aplastic / diagnosis
  • Anemia, Aplastic / immunology
  • Anemia, Aplastic / therapy
  • Antilymphocyte Serum / therapeutic use
  • Blood Transfusion
  • Bone Marrow Examination
  • Celiac Disease / complications*
  • Celiac Disease / diagnosis
  • Celiac Disease / diet therapy
  • Celiac Disease / immunology
  • Child
  • Diet, Gluten-Free
  • Fatal Outcome
  • Humans
  • Male
  • Medication Adherence
  • Steroids / therapeutic use
  • Time Factors
  • Treatment Outcome

Substances

  • Antilymphocyte Serum
  • Steroids