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Case Reports
. 2014 Jun;32(2):367-71.

Cerebral Atrophy in a Vitamin B12-deficient Infant of a Vegetarian Mother

Free PMC article
Case Reports

Cerebral Atrophy in a Vitamin B12-deficient Infant of a Vegetarian Mother

Celebi Kocaoglu et al. J Health Popul Nutr. .
Free PMC article

Abstract

In developed countries, vitamin B12 (cobalamin) deficiency usually occurs in children, exclusively breastfed ones whose mothers are vegetarian, causing low body stores of vitamin B12. The haematologic manifestation of vitamin B12 deficiency is pernicious anaemia. It is a megaloblastic anaemia with high mean corpuscular volume and typical morphological features, such as hyperlobulation of the nuclei of the granulocytes. In advanced cases, neutropaenia and thrombocytopaenia can occur, simulating aplastic anaemia or leukaemia. In addition to haematological symptoms, infants may experience weakness, fatigue, failure to thrive, and irritability. Other common findings include pallor, glossitis, vomiting, diarrhoea, and icterus. Neurological symptoms may affect the central nervous system and, in severe cases, rarely cause brain atrophy. Here, we report an interesting case, a 12-month old infant, who was admitted with neurological symptoms and diagnosed with vitamin B12 deficiency.

Figures

Figure 1.
Figure 1.
Facial appearence of the patient (marked rhagades around the angles of both eyelids and mouth)
Figure 2.
Figure 2.
Initial MR images: axial (A) and coronal (B) T2-weighted images showed severe cerebral atrophy with enlargement of cortical sulci and subarachnoid spaces (arrows)
Figure 3.
Figure 3.
Control MR images after therapy. Axial (A) and coronal (B) T2-weighted images demonstrated recovery of cerebral atrophy. Subarachnoid space width was in normal range (arrows)

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