[Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in the acute phase of alloxan-induced diabetes in rats]

Eksp Klin Farmakol. 2014;77(4):14-20.
[Article in Russian]

Abstract

The effect of derivatives of 3-oxypyridine and succinic acid (emoxypine, reamberin, and mexidol) on the manifestations of anxiety (according to the criteria of behavior in elevated cross plus maze test) depression (according to the criterian of immobility in the Porsolt test) in the acute phase of alloxan diabetes (96 h after alloxan administration) has been studied in rats. The effectiveness of emoxypine, reamberin, and mexidol was compared with that of alpha-lipoic acid (etalon treatment of diabetic neuropathy). It was established that a single administration of 3-oxypyridine and succinic acid derivatives in doses equivalent to the therapeutic range for humans corrected anxio-depressive disorders in the acute phase of alloxan diabetes, while being not inferior to alpha-lipoic acid with respect to the intensity of anxiolytic and antidepressant action. The correction of affective disorders by emoxypine, reamberin and mexidol did not depend on their effect on hyperglycemia in the acute phase of alloxan diabetes. The most pronounced anxiolytic action was observed upon the administration of emoxypine, while the most pronounced antidepressant effect was observed upon the administration of mexidol.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Anti-Anxiety Agents / pharmacology*
  • Antidepressive Agents / pharmacology*
  • Behavior, Animal / drug effects*
  • Diabetes Mellitus, Experimental / physiopathology*
  • Diabetic Neuropathies / physiopathology
  • Maze Learning / drug effects
  • Pyridines / pharmacology*
  • Rats
  • Succinates / pharmacology*

Substances

  • 3-oxypyridine
  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Pyridines
  • Succinates