Parvovirus-derived endogenous viral elements in two South American rodent genomes

J Virol. 2014 Oct;88(20):12158-62. doi: 10.1128/JVI.01173-14. Epub 2014 Jul 30.


We describe endogenous viral elements (EVEs) derived from parvoviruses (family Parvoviridae) in the genomes of the long-tailed chinchilla (Chinchilla lanigera) and the degu (Octodon degus). The novel EVEs include dependovirus-related elements and representatives of a clearly distinct parvovirus lineage that also has endogenous representatives in marsupial genomes. In the degu, one dependovirus-derived EVE was found to carry an intact reading frame and was differentially expressed in vivo, with increased expression in the liver.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chinchilla / genetics*
  • Chinchilla / virology
  • Genome*
  • Molecular Sequence Data
  • Parvovirus / classification
  • Parvovirus / genetics*
  • Phylogeny
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Homology, Amino Acid