Cyclical dehydration-induced renal injury and Mesoamerican nephropathy: as sweet by any other name?

Kidney Int. 2014 Aug;86(2):226-9. doi: 10.1038/ki.2014.47.


Severe cyclical dehydration induces chronic renal injury in rodents. This effect is attenuated by global fructokinase deficiency, suggesting possible roles for fructokinase and fructose metabolism in mediating or promoting dehydration-induced injury. Clinical and pathological similarities between this injury model and endemic Mesoamerican nephropathy (MeN) have fueled speculation that dehydration-induced injury and MeN may share common mechanistic underpinnings involving fructokinase that can be targeted to mitigate disease development, progression, and/or severity.

Publication types

  • Comment

MeSH terms

  • Animals
  • Dehydration / enzymology*
  • Fructokinases / metabolism*
  • Kidney / injuries*
  • Male


  • Fructokinases
  • ketohexokinase