Thirteenfold increase of chromosomal aberrations non-randomly distributed in chagasic children treated with nifurtimox

Mutat Res. 1989 Oct;224(2):263-7. doi: 10.1016/0165-1218(89)90165-1.


Chromosomal aberrations were analyzed from cultures of peripheral lymphocytes in 2 groups of chagasic children, before and after treatment with nifurtimox. The mean incidence of chromosomal aberrations increased from control values of 1.75 +/- 1.39 (8 patients) to 23.55 +/- 9.55 (6 patients) at a significance of P less than 0.0001. G-banding analysis of chromosomal aberration sites revealed that treated patients present coincidence in the chromosome regions affected: 1p11, 1q11-12, 9q11-13, 17q11-21, 2p21, 2q23, 2q31, 2q33, 6p21, 6p21, 7q32, 13q14, 13q22, 15q22. These data indicate a non-random distribution of chromosomal aberrations induced by nifurtimox therapeutic treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Chagas Disease / drug therapy*
  • Child
  • Child, Preschool
  • Chromosome Aberrations*
  • Chromosome Banding
  • Female
  • Humans
  • Infant
  • Male
  • Nifurtimox / therapeutic use
  • Nifurtimox / toxicity*
  • Nitrofurans / toxicity*


  • Nitrofurans
  • Nifurtimox