Effects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: a randomized controlled clinical trial

Hormones (Athens). 2014 Jul-Sep;13(3):398-406. doi: 10.14310/horm.2002.1489.


Objective: The aim of this study was to determine the effects of synbiotic food consumption on glycemic status and serum high sensitivity C-reactive protein (hs-CRP) levels of Iranian pregnant women.

Design: This randomized placebo-controlled clinical trial was performed among 52 pregnant women, primigravida, aged 18-35 year old, in their third trimester. After a 2-wk run-in period, subjects were randomly assigned to consume either a synbiotic (n=26) or control food (n=26) for 9 weeks. The synbiotic food consisted of a probiotic Lactobacillus sporogenes (1×107 CFU), 0.04 g inulin as prebiotic with 0.38 g isomalt, 0.36 g sorbitol and 0.05 g stevia as sweetener per 1 g. Control food (the same substance without probiotic bacteria and inulin) was packed in identical 9-gram packages. Patients were asked to consume the synbiotic and control foods two times a day. Fasting blood samples were taken at baseline and after a 9-wk intervention for quantification of related factors.

Results: Consumption of a synbiotic food did not show any significant change regarding the impact of insulin actions in the synbiotic group; nonetheless, compared to the control food, it resulted in a significant decrease in serum insulin levels (-0.26 vs. 6.34 µIU/mL, P=0.014) and HOMA-IR (-0.13 vs. 1.13, P=0.033), a significant difference in HOMA-B (5.30 vs. 34.22, P=0.040) and a significant rise in QUICKI score (0.002 vs. -0.02, P=0.022).

Conclusions: Consumption of a synbiotic food for 9 weeks by pregnant women had beneficial effects on insulin actions compared to the control food, but did not affect FPG and serum hs-CRP concentrations.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers / blood*
  • Blood Glucose / metabolism*
  • C-Reactive Protein / metabolism*
  • Diet*
  • Disaccharides / administration & dosage
  • Female
  • Humans
  • Insulin / blood
  • Inulin / administration & dosage
  • Iran
  • Lactobacillus / classification
  • Lactobacillus / physiology
  • Nutritional Status
  • Prebiotics*
  • Pregnancy
  • Pregnancy Trimester, Third / blood
  • Prenatal Nutritional Physiological Phenomena*
  • Probiotics / administration & dosage*
  • Sorbitol / administration & dosage
  • Stevia
  • Sugar Alcohols / administration & dosage
  • Sweetening Agents / administration & dosage
  • Synbiotics*
  • Time Factors
  • Treatment Outcome
  • Young Adult


  • Biomarkers
  • Blood Glucose
  • Disaccharides
  • Insulin
  • Prebiotics
  • Sugar Alcohols
  • Sweetening Agents
  • Sorbitol
  • Palatinit
  • Inulin
  • C-Reactive Protein

Associated data

  • IRCT/201212105623N3