Beneficial effects of hyaluronic acid

Adv Food Nutr Res. 2014:72:137-176. doi: 10.1016/B978-0-12-800269-8.00009-9.


Biomaterials are playing a vital role in our day-to-day life. Hyaluronan (hyaluronic acid), a biomaterial, receives special attention among them. Hyaluronic acid (HA) is a polyanionic natural polymer occurring as linear polysaccharide composed of glucuronic acid and N-acetylglucosamine repeats via a β-1,4 linkage. It is the most versatile macromolecule present in the connective tissues of all vertebrates. Hyaluronic acid has a wide range of applications with its excellent physicochemical properties such as biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity and serves as an excellent tool in biomedical applications such as osteoarthritis surgery, ocular surgery, plastic surgery, tissue engineering, and drug delivery. It plays a key role in cushioning and lubricating the body and is abundant in the eyes, joints, and heart valves. A powerful antioxidant, hyaluronic acid is perhaps best known for its ability to bond water to tissue. Hyaluronan production increases in proliferating cells, and the polymer may play a role in mitosis. This chapter gives an overview of hyaluronic acid and its physicochemical properties and applications. This chapter gives a deep understanding on the special benefits of hyaluronic acid in the fields of pharmaceutical, medical, and environmental applications. Hyaluronic acid paves the way for beneficial research and applications to the welfare of life forms.

Keywords: Applications; Hyaluronic acid; Physicochemical properties; Structure.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / therapeutic use
  • Antineoplastic Agents
  • Biomedical Technology
  • Chemical Phenomena
  • Drug Delivery Systems
  • Genetic Therapy / methods
  • Humans
  • Hyaluronic Acid* / chemistry
  • Hyaluronic Acid* / therapeutic use
  • Hydrogels
  • Molecular Structure
  • Regeneration
  • Solubility
  • Solutions
  • Tissue Engineering


  • Anti-Infective Agents
  • Antineoplastic Agents
  • Hydrogels
  • Solutions
  • Hyaluronic Acid