Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance

H Guio; D Tarazona; M Galarza; V Borda; R Curitomay

doi:10.1128/genomeA.00759-14

Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance

Genome Announc. 2014 Jul 31;2(4):e00759-14. doi: 10.1128/genomeA.00759-14.

Authors

H Guio¹, D Tarazona², M Galarza², V Borda², R Curitomay³

Affiliations

¹ hguio@ins.gob.pe.
² Laboratorio de Biotecnología y Biología Molecular, Instituto Nacional de Salud (INS), Lima, Peru.
³ Departamento de Neumología, Hospital Nacional Hipólito Unanue, Lima, Peru.

Abstract

We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.