Evaluation of quality of life and anxiety and depression levels in patients receiving chemotherapy for colorectal cancer: impact of patient education before treatment initiation

J Gastrointest Oncol. 2014 Aug;5(4):270-5. doi: 10.3978/j.issn.2078-6891.2014.034.


Background: As a consequence of the improved survival due to the availability of several treatment option cost-effectiveness and health-related quality of life (HRQoL) issues have gained increasing attention in colorectal cancer (CRC). In the present study, we aimed to evaluate quality of life, level of anxiety and depression before and after a 6-month follow-up period in chemotherapy receiving patients with CRC.

Methods: The study was conducted in 50 patients with colon or rectal cancer. All patients were informed and educated about their disease and treatment before getting the treatment and were followed for 6 months, during which they received chemotherapy. A "Questionnaire Form" to collect patient demographic characteristics; the "EORTC QLQ-C30 Scale" and "EQ-5D Scale" to evaluate patient's quality of life; and the "Hospital Anxiety and Depression (HAD) Scale" to evaluate the level of anxiety and depression status of patients, were used as data collecting tools.

Results: Quality of life scores in all functional fields were high in the sixth course when compared to the first according to EORTC QLQ-C30 Scale, reaching to statistically significant level in emotional function score compared to the initial ones (P<0.05). Moreover quality of life score measured in the sixth month with EQ-5D was statistically significantly higher than the initial.

Conclusions: These data, shows that with proper patient management, quality of life score, and the anxiety and depression levels improve during the course of treatment.

Keywords: Education; anxiety; colorectal cancer (CRC); depression; patient; quality of life.