Tertiary lymphoid tissue: A gateway for T cells in the tumor microenvironment

Oncoimmunology. 2014 May 15;3:e28850. doi: 10.4161/onci.28850. eCollection 2014.


Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.

Keywords: biomarkers; colorectal cancer; immunotherapy; prognosis; tertiary lymphoid tissue; tumor-infiltrating lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't