Immune cells in pancreatic cancer: Joining the dark side

Oncoimmunology. 2014 Jun 5;3:e29125. doi: 10.4161/onci.29125. eCollection 2014.


Pancreatic tumors are rich in immune cell infiltrates that include CD4+ T-cell subsets encompassing both regulatory T cells and TH17 cells. Rather than protecting the organism by exerting an anticancer effect, these T-cell subsets promote tumor formation. Thus, re-activation of antitumor immunity should be investigated for use in pancreatic cancer prevention and therapy.

Keywords: CD4 T cells; CD8 T cells; IL-17; Kras; TH17 cells; mouse model; pancreatic cancer; regulatory T cells.