BRAF-targeted therapy alters the functions of intratumoral CD4 + T cells to inhibit melanoma progression

Oncoimmunology. 2014 Jun 18;3:e29126. doi: 10.4161/onci.29126. eCollection 2014.

Abstract

The establishment of an immunosuppressive tumor microenvironment is a hallmark feature driving cancer cell evasion of immunosurveillance. In a murine melanoma model, we recently demonstrated that decreased intratumoral CD4+ T-cell expression of CD40L and interferon γ (IFNγ) is critical to maintain this immunosuppressive microenvironment. Altered effector functions of tumor-associated CD4+ T cells is essential for B-RafV600E inhibitor-mediated restoration of antitumor immunity.

Keywords: BRAF; CD40L; IFNγ; T cell; melanoma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't