Chance, destiny, and the inner workings of ClpXP

Cell. 2014 Jul 31;158(3):479-80. doi: 10.1016/j.cell.2014.07.009.


AAA+ proteases are responsible for protein degradation in all branches of life. Using single-molecule and ensemble assays, Cordova et al. investigate how the bacterial protease ClpXP steps through a substrate's polypeptide chain and construct a quantitative kinetic model that recapitulates the interplay between stochastic and deterministic behaviors of ClpXP.

Publication types

  • Comment

MeSH terms

  • Endopeptidase Clp / chemistry*
  • Endopeptidase Clp / metabolism*


  • ClpP protein, human
  • Endopeptidase Clp
  • CLPX protein, human