The Microbial Basis of Inflammatory Bowel Diseases

J Clin Invest. 2014 Oct;124(10):4190-6. doi: 10.1172/JCI72330. Epub 2014 Aug 1.

Abstract

Inflammatory bowel diseases (IBD) are chronic, progressive diseases characterized by aberrant immune responses to environmental and gut microbial triggers in genetically susceptible hosts. Clinical, genetic, and experimental data support the role of gut microbes in causing and sustaining these diseases. Our understanding of IBD has changed dramatically as the result of advances in cultivation-independent approaches and computational platforms for the analysis of large data sets. However, investigations relevant to clinical observations and the natural history of the diseases will be essential for the development of microbial, genetic, and biological metrics that may be used to individualize assessment of risk and improve clinical outcomes in IBD.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Disease Progression
  • Dysbiosis / microbiology*
  • Gastrointestinal Tract
  • Genetic Predisposition to Disease
  • Genome
  • Humans
  • Immune System
  • Inflammation
  • Inflammatory Bowel Diseases / microbiology*
  • Intestines / microbiology*
  • Metagenome
  • Microbiota*
  • Treatment Outcome