The potential role of HPV vaccination in the prevention of infectious complications of pregnancy

Expert Rev Vaccines. 2014 Nov;13(11):1307-16. doi: 10.1586/14760584.2014.944164. Epub 2014 Aug 1.


There is now incontrovertible evidence that HPV is the cause of almost all cases of genital warts, cervical dysplasia and cervical cancer. Moreover the current review of the recent literature on HPV in relation to pregnancy found strong indications that HPV plays an important role in adverse outcomes of pregnancy. HPV may contribute to infertility and may increase the risk of miscarriage. Recent studies indicate a significant rate of vertical transmission of HPV between mother and child but whether the mode of delivery makes a difference to the risk of transmission remains unknown. HPV infection appears to be correlated with both spontaneous preterm birth and preterm prelabor rupture of the membranes.

Keywords: HPV; condylomata acuminata; infertility; miscarriage; pregnancy; pregnancy outcome; preterm birth; preterm prelabour rupture of the membrane; semen.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Abortion, Spontaneous / prevention & control
  • Female
  • Humans
  • Infectious Disease Transmission, Vertical / prevention & control
  • Papillomavirus Infections / prevention & control*
  • Papillomavirus Infections / transmission
  • Papillomavirus Vaccines / administration & dosage*
  • Papillomavirus Vaccines / immunology*
  • Pregnancy
  • Pregnancy Complications, Infectious / prevention & control*
  • Vaccination / methods*


  • Papillomavirus Vaccines