Non-rash dermatologic adverse events related to targeted therapies

Semin Oncol Nurs. 2014 Aug;30(3):155-68. doi: 10.1016/j.soncn.2014.05.003.


Objectives: To provide background information and management strategies for non-rash dermatological adverse events.

Data sources: Peer-reviewed journal articles, professional manuals, online sources.

Conclusion: During the last decade, many dermatological adverse events of targeted therapy have been reported, including xerosis, skin fissures, pruritus, photosensitivity, pigmentation changes, hair and nail changes, hand-foot skin reaction, squamoproliferative lesions, Stevens-Johnsons syndrome, and toxic epidermal necrolysis. Although evidenced-based treatment options are scarce, many recommendations have been described in the literature that should be considered to apply in daily practice.

Implications for nursing practice: Nursing practice will be enhanced by education, assessment, and management recommendations.

Keywords: Targeted therapy; assessment; education; management; non-rash adverse events.

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Humans
  • Molecular Targeted Therapy / adverse effects*
  • Neoplasms / drug therapy*


  • Antineoplastic Agents