Determination of prostaglandin analogs in cosmetic products by high performance liquid chromatography with tandem mass spectrometry

J Chromatogr A. 2014 Sep 12:1359:140-6. doi: 10.1016/j.chroma.2014.07.032. Epub 2014 Jul 19.

Abstract

A method was developed and validated for the determination of 16 prostaglandin analogs in cosmetic products. The QuEChERS (Quick, Easy, Cheap, Efficient, Rugged, Safe) liquid-liquid extraction method, typically used for pesticide residue analysis, was utilized as the sample preparation technique. The prostaglandin analogs were chromatographically separated and quantified using high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). Thirty-one cosmetic products were surveyed, and 13 products were determined to contain a prostaglandin analog with amounts ranging from 27.4 to 297μg/g. The calculated concentrations for the cosmetic products were in a similar range when compared to the concentrations of three different prostaglandin analog-containing prescription products.

Keywords: Cosmetics; LC-MS/MS; Prostaglandins; QuEChERS.

Publication types

  • Evaluation Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromatography, High Pressure Liquid / methods*
  • Cosmetics / chemistry*
  • Molecular Structure
  • Prostaglandins, Synthetic / chemistry*
  • Prostaglandins, Synthetic / isolation & purification
  • Solid Phase Extraction
  • Tandem Mass Spectrometry / methods*

Substances

  • Cosmetics
  • Prostaglandins, Synthetic