Cold Spring Harb Perspect Med. 2014 Aug 1;4(8):a015354. doi: 10.1101/cshperspect.a015354.


Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes and results from the interplay of genetic, environmental, and immunological factors. Four decades of clinical and basic research on psoriasis have elucidated many of the pathogenic mechanisms underlying disease and paved the way to effective targeted therapies. Here, we review this progress and identify future directions of study that are supported by a more integrative research approach and aim at further improving the patients' life.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Biological Factors / therapeutic use
  • Biomarkers / metabolism
  • Dermatologic Agents / therapeutic use
  • Environment
  • Forecasting
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Immune System / physiology
  • Proteins / genetics
  • Psoriasis / classification
  • Psoriasis / etiology*
  • Psoriasis / therapy


  • Antibodies, Monoclonal
  • Biological Factors
  • Biomarkers
  • Dermatologic Agents
  • PSORS1C1 protein, human
  • Proteins