Clinicopathologic study of salivary duct carcinoma and the efficacy of androgen deprivation therapy

Am J Otolaryngol. Nov-Dec 2014;35(6):731-5. doi: 10.1016/j.amjoto.2014.07.007. Epub 2014 Jul 10.

Abstract

Objective: Salivary duct carcinoma is a rare and aggressive tumor of the salivary glands. The objectives of this study were to investigate the clinicopathological features of salivary duct carcinoma and to determine whether androgen deprivation therapy should be recommended.

Study design and methods: The clinical records of seven patients diagnosed with salivary duct carcinoma between 2002 and 2012 were retrospectively assessed. Tumor specimens were examined for overexpression of human epidermal growth factor receptor 2 (HER2) and androgen receptor by immunohistochemistry. A case of androgen receptor-positive salivary duct carcinoma who received androgen deprivation therapy is presented.

Results: Of the seven patients, 43% had recurrences and metastases, and the 5-year survival rate was 68.6%. All patients were androgen receptor-positive, and 71% were HER2-positive. One patient, a 66-year-old man with androgen receptor-positive salivary duct carcinoma, received oral bicalutimide for 14 months and practically all lung metastases disappeared.

Conclusion: Androgen receptor is often overexpressed in salivary duct carcinoma. Androgen deprivation therapy is safe and should be considered for patients with androgen receptor-positive salivary duct carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Androgen Antagonists / therapeutic use*
  • Anilides / therapeutic use*
  • Female
  • Humans
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Nitriles / therapeutic use*
  • Prognosis
  • Receptor, ErbB-2 / metabolism*
  • Receptors, Androgen / metabolism*
  • Salivary Ducts*
  • Salivary Gland Neoplasms / drug therapy
  • Salivary Gland Neoplasms / metabolism
  • Salivary Gland Neoplasms / pathology*
  • Tosyl Compounds / therapeutic use*

Substances

  • Androgen Antagonists
  • Anilides
  • Nitriles
  • Receptors, Androgen
  • Tosyl Compounds
  • bicalutamide
  • ERBB2 protein, human
  • Receptor, ErbB-2