RETRACTED: Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice

Neuropharmacology. 2014 Nov:86:192-202. doi: 10.1016/j.neuropharm.2014.07.012. Epub 2014 Jul 31.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. It has been highlighted that there is image manipulation. Fig. 6 b), e) ad f) are the same images from Fig 5 a), b), c) from Patil, S.P., Jain, P.D., Ghumatkar, P.J., Tambe, R., Sathaye, S., 2014. Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice. Neuroscience 277, 747–754 and used to describe different drug doses and treatments in the paper. Fig. 8 d), e) and f) are the same image manipulated to be results for different drug treatments. Fig. 10a), b) and h) are the same images as Fig. 7 B) in the paper Patil, S.P., Jain, P.D., Ghumatkar, P.J., Tambe, R., Sathaye, S., 2014. Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice. Neuroscience 277, 747–754 and used to describe different drug treatments. The authors acknowledge there are serious errors and agree with the retraction of this paper.

Keywords: Apigenin; Luteolin; Neuroprotective; Neurotrophic; Parkinson's disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Animals
  • Apigenin / pharmacology*
  • Brain-Derived Neurotrophic Factor / metabolism
  • Bromocriptine / pharmacology
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Glial Fibrillary Acidic Protein / metabolism
  • Luteolin / pharmacology*
  • MPTP Poisoning / drug therapy*
  • MPTP Poisoning / pathology
  • MPTP Poisoning / physiopathology
  • Male
  • Mice
  • Motor Activity / drug effects
  • Motor Activity / physiology
  • Neuroprotective Agents / pharmacology*
  • Oxidative Stress / drug effects
  • Oxidative Stress / physiology
  • Pars Compacta / drug effects
  • Pars Compacta / pathology
  • Pars Compacta / physiopathology
  • Random Allocation
  • Tumor Necrosis Factor-alpha / metabolism
  • Tyrosine 3-Monooxygenase / metabolism

Substances

  • Brain-Derived Neurotrophic Factor
  • Glial Fibrillary Acidic Protein
  • Neuroprotective Agents
  • Tumor Necrosis Factor-alpha
  • Bromocriptine
  • Apigenin
  • Tyrosine 3-Monooxygenase
  • Luteolin